Cancer is one of the most fatal chronic diseases in existence today. Several years of research and experiments have failed to find a cure for this disease. According to a World Health Organization report, ten million new cancers are diagnosed each year and if not prevented, then the number is estimated to rise to 20 million in the next 17 years. Also, prevalent treatments like chemotherapies and radiation haven’t proved to be an ultimate solution and can only help prolong a patient’s life by a bit. Moreover, these conventional therapies are very expensive in several countries and it drains a lot of wealth to treat cancer.
Several studies and research have shown that phytochemicals found in vegetables and fruits exhibit chemopreventive and therapeutic properties against such cancers. One analog of Vitamin E, the Tocotrienol, has been observed to exhibit incredible anticancer, anti-inflammatory, and antioxidant properties! Delta Gold Tocotrienols are natural antioxidants that possess 50 times more antioxidant and anticancer properties as compared to the Tocopherol-based Vitamin E supplement.
Tocotrienol based Vitamin E Supplement: An Overview
Vitamin E is a family of two analogs, Tocopherols and Tocotrienols. And both these groups have four isoforms– Alpha, Beta, Gamma, and Delta. In several kinds of research, it has been observed that Tocopherol based Vitamin E Supplement barely helps in preventing or suppressing cancer, while DeltaGold Tocotrienol has shown incredible activities against certain kinds of cancers! Tocotrienols are super rare, and it is tough to obtain them in their purest form. Palm, Rice, and Annatto plants are included in the major sources of Tocotrienols, but only Annatto plant is the source of 100% pure Tocotrienols.Tocotrienol was discovered in 1956, and its anti-cancer properties were observed in 1985 for the first time. But with the onset of the 21st century, extensive studies and research were carried out to demonstrate the anticancer properties of Tocotrienols and the results simply astounded the scientists!
DeltaGold Tocotrienol and its Action against certain Cancers
Tocotrienol has shown incredible anticancer activities in the treatment and prevention of certain cancers. Below, I have listed a few cancers and an overview of how Tocotrienols help you fight such deadly diseases. You can study the studies and research in detail on the internet and on websites like NCBI and WebMD.
- Breast Cancer
Studies have demonstrated that Tocotrienols-based Vitamin E Supplement may prevent and suppress breast cancer because DeltaGold Tocotrienol has been observed to exhibit chemopreventive and anticancer activities against breast cancer in vitro and in vivo studies. Tocotrienol has been observed to suppress the growth of both estrogen-receptor-positive (ER+) and estrogen-receptor-negative (ER-) phenotypes of breast cancer cells by inhibiting HMGCR activity. It has also been observed that DeltaGold Tocotrienol suppresses the proliferation of breast cancer cells by altering the expression of oxidative stress modulatory enzymes GPX, SOD, NQO1, and NQO2, and cell cycle regulatory proteins (Rb/E2F complex, cyclin D1/CDK-4, and cyclin B1/CDK-1).
- Colorectal Cancer
Tocotrienol-based Vitamin E supplement has been observed to significantly inhibit the proliferation of colon cancer cells through downregulation of β-catenin, c-jun, cyclin D1, and Wnt-1. Also, Gamma-Tocotrienol has shown that it suppresses the proliferation of HT-29 colon cancer cells by downregulating Bcl-2 and upregulating caspase-3 and Bax. Delta-Tocotrienol has been observed to suppress PKC activity in colorectal adenocarcinoma cells, thus reducing telomerase activity and hence suppressing the spread of cancer. Delta-Tocotrienol and Gamma-Tocotrienol (DeltaGold Tocotrienol) induce apoptosis in colon cancer cells by downregulating NF-kB and its regulated gene products.
It has been observed that DeltaGold Tocotrienol exerts a marked cytotoxic effect against human T-cell lymphoblastic leukemia cells. Gamma Tocotrienol has also demonstrated cytotoxicity in various leukemia cell types like myeloblastic, relapsed leukemia, and lymphoblastic showing its anticancer activity against leukemia cells. Also, Tocotrienols have been observed to induce apoptosis I leukemia by inhibiting NF-kB activating the caspase cascade, increasing cyt.c release, and Bid cleavage. Also, a mixture of Delta-Tocotrienol and its peroxy dimer have been reported to trigger apoptosis through the mitochondrial pathway, thus suppressing the growth and survival chances of leukemia cancer cells.
Delta-Tocotrienol has been observed to induce marked cytotoxicity in SF-295 glioblastoma cells, thus suppressing cancer. In research, DeltaGold Tocotrienolhas been observed to activate caspase-8 and enhance mitochondrial cytochrome c (cyt. c) release due to loss of mitochondrial membrane integrity which leads to induction of apoptosis in glioblastoma.
- Gastric Cancer
Tocotrienol has been incorporated for the prevention and treatment of gastric cancer in several studies. It has been reported to suppress the growth and proliferation of human gastric cancer by inhibiting NF-kB pathway. Gamma-Tocotrienol has also been seen to induce apoptosis by activating caspase-9 and downregulating the Raf-ERK signaling pathway. It has also been demonstrated that Gamma-Tocotrienol inhibits the paracrine secretion of VEGF through suppression of pERK1/2, thus demonstrating its anti-angiogenic ability. Gamma-Tocotrienol has demonstrated that it can downregulate MMP-2, -9, and upregulated tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 in vitro, thus emphasizing its anti-metastatic property against cancer.
- Prostate Cancer
DeltaGold Tocotrienol has elucidated tremendous potential in the prevention and treatment of prostate cancer. Studies have shown that Tocotrienol promotes autophagy and apoptosis in human prostate cancer cells. Supplementation of Gamma-Tocotrienol had significantly reduced the tumor growth of the LNCaP-xenograft mouse model. Tocotrienol has also been observed to inhibit androgen-independent prostate cancer cell proliferation through simultaneous inhibition of tyrosine kinase, Src, and STAT3. Tocotrienol can induce apoptosis in prostate cancer cells throughactivating the JNK-signaling pathway and inhibition of TGFβ2,Fyn/HIF-1α, NF-κB, EGFR, and Id family proteins (Id1 and Id3).
- Lung Cancer
Lim et al. has revealed that Tocotrienols induce apoptosis in lung cancer cells through the activation of mitochondrial cyt.c release and caspase-8. It has also been observed to elevate microRNA, miR-34a, which leads to the downregulation of Notch-1 and its downstream targets cyclin D1, surviving, and Bcl-2. Tocotrienol-based Vitamin E Supplement can suppress hypoxia adaptation of lung cancer cells and induce apoptosis in human lung adenocarcinoma cells.
- Liver Cancer
In the past two decades, very promising studies have come up demonstrating the anticancer effects of Tocotrienol against HCC or hepatocellular carcinoma. Tocotrienol cab inhibits the proliferation of HCC cells by upregulating Prx4. Gamma-Tocotrienol has displayed its apoptotic and anti-proliferative activities against HCC by upregulation of caspase-8, caspase-9, and Bax, by inhibiting STAT3 and its regulated gene productsBcl-xL, survivin,Mcl-1,Bcl-2,cyclin D1,and VEGF, and by increasing Bid fragmentation. Gamma-Tocotrienol has also been observed to lower lipids in HCC which contributes to its anti-cancer properties.
- Pancreatic Cancer
Several in vivo and in vitro studies have demonstrated the therapeutic and chemopreventive potential of Tocotrienol against pancreatic cancer. DeltaGold Tocotrienol can suppress pancreatic cancer cells growth via inhibition of the NF-kB activation of its regulated gene products like CXCR-4, cyclin D1,c-Myc,VEGF, MMP-9, and so on. Delta-Tocotrienol has been observed to suppress the progression of pancreatic intraepithelial neoplasm (PIN) in Kras transgenic mouse model via inhibition of Kras-driven pathways like PI3K/Akt, NF-kB, and MEK/ERK, and enhanced caspase-3 and Bax activities. Delta-Tocotrienol induces G1 cell cycle arrest by elevating nuclear accumulation of p27 (Kip1). One recent study has also demonstrated that DeltaGold Tocotrienol significantly inhibits the metastasis of pancreatic ductal adenocarcinoma (PDAC) and PDAC stem-like cells.
The above activities which I have mentioned related to the properties of Tocotrienol have been taken from various studies and research which have demonstrated the potency of Tocotrienol in battling several kinds of cancers. Tocotrienol-based Vitamin E Supplement has turned out to be a very promising agent in the battle against cancer. For all the studies in detail, you can read them at websites like ncbi.com and webmd.com.